Chaenomeles Sinensis: A Potent α-and β-Glucosidase Inhibitor
نویسندگان
چکیده
منابع مشابه
Production of α - Glucosidase Inhibitor by β - Glucosidase Inhibitor - Producing
A soil microorganism producing αand β-glucosidase inhibitors was identified as Bacillus lentimorbus, based on the fatty acid and morphological analyses, along with biochemical and physiological tests. The α-glucosidase inhibitor was highly produced by this strain in a culture medium containing 0.25% of sodium glutamate and 0.5% of glucose, pH 8.0 at 30C for 2 days. The α-glucosidase inhibitor f...
متن کاملPolyopes lancifolia Extract, a Potent α-Glucosidase Inhibitor, Alleviates Postprandial Hyperglycemia in Diabetic Mice
This study was designed to investigate the inhibitory effects of Polyopes lancifolia extract (PLE) on α-glucosidase activity, α-amylase activitiy, and postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. The results of this study revealed a marked inhibitory effect of PLE on α-glucosidase and α-amylase activities. The IC50s of PLE against α-glucosidase and α-amylase were 0....
متن کاملSearch for independent (β/α)4 subdomains in a (β/α)8 barrel β-glucosidase
Proteins that fold as (β/α)8 barrels are thought to have evolved from half-barrels that underwent duplication and fusion events. The evidence is particularly clear for small barrels, which have almost identical halves. Additionally, computational calculations of the thermodynamic stability of these structures in the presence of denaturants have revealed that (β/α)8 barrels contain two subunits ...
متن کاملΑ-glucosidase inhibitor isolated from coffee.
The potent α-glucosidase inhibitor (compound I) was isolated from coffee brews by the activity-based fractionation and identified as a β-carboline alkaloid norharman (9H-pyrido[ 3.4-b]indole) on the basis of mass spectroscopy and nuclear magnetic resonance spectra ((1)H NMR, (13)C NMR, and COSY). The norharman showed a potent inhibition against α-glucosidase enzyme in a concentration dependent ...
متن کاملDesign and Synthesis of New Benzimidazole and Pyrimidine Derivatives as α-glucosidase Inhibitor
In an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (POCl3). The synthesized compounds were identified by 1H-NMR, 13C-NMR, FT-IR spectroscopic techniques and elemental analysis. All products were...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Pharmacology and Toxicology
سال: 2009
ISSN: 1557-4962
DOI: 10.3844/ajptsp.2009.8.11